Luxembourg for Business (LfB) was founded in April 2008 as an initiative by the Ministry of the Economy and Foreign Trade, the Ministry of Small and Medium-Sized Businesses and Tourism, the Chamber of Commerce, the Office du Ducroire, the National Credit an Investment Corporation (SNCI), the Chamber of Crafts and Luxembourg's Business Federation (FEDIL).

Relying on the strengths of both public and private partners, Luxembourg for Business operates as a trade promotion agency and liaises with Luxembourg's Trade & Investment Offices, its Embassies, Consulate Generals, Honorary Consulates, and other international promotion networks such as for example bilateral Chamber of Commerce  to foster Luxembourg's outbound activities. With a Secretary General and an assistant, Luxembourg for Business functions as a so-called "network agency" establishing a platform for its members to review, coordinate and improve their efforts.